AlphaFold: de grote uitdaging van 50 jaar, gekraakt door AI AlphaFold: The 50-year grand challenge cracked by AI

Een halve eeuw lang worstelden wetenschappers met de vraag hoe eiwitten vouwen. Een puzzel die de kern raakt van hoe we het leven begrijpen en ziektes genezen. Vijf jaar geleden kraakte het #alphafold-team de code. Sindsdien hebben meer dan 3 miljoen onderzoekers in ruim 190 landen de vrij beschikbare database van AlphaFold met meer dan 200 miljoen eiwitstructuren gebruikt. Dat versnelt ontdekkingen in van alles, van medicijnontwerp tot ziekteresistente gewassen, de bescherming van bijen en plasticetende enzymen. Meer info: https://deepmind.google/blog/alphafold-five-years-of-impact Luister naar Nobelprijswinnaar John Jumper: https://youtu.be/-pGs0btGmgY ____ Verder lezen: Een paar voorbeelden van hoe onderzoekers wereldwijd AlphaFold gebruiken (in volgorde van verschijnen): Chili, Duitsland: Engineering the catalytic activity of an Antarctic PET-degrading enzyme by loop exchange: https://onlinelibrary.wiley.com/doi/abs/10.1002/pro.4757 Verenigd Koninkrijk: AlphaFold-Multimer predicts cross-kingdom interactions at the plant-pathogen interface: https://www.nature.com/articles/s41467-023-41721-9 Verenigde Staten: Increasing thermostability of the key photorespiratory enzyme glycerate 3-kinase by structure-based recombination: https://onlinelibrary.wiley.com/doi/10.1111/pbi.14508 Verenigde Staten: The structure of apolipoprotein B100 from human low-density lipoprotein: https://www.nature.com/articles/s41586-024-08467-w Noorwegen, Portugal, VS, VK: Cryo-EM structure of native honey bee vitellogenin: https://www.nature.com/articles/s41467-025-58575-y Spanje: Identification of novel compounds against Trypanosoma cruzi using AlphaFold structures: https://linkinghub.elsevier.com/retrieve/pii/S2001037025001655 Frankrijk: Structural basis for hepatitis E virus neutralization by potent human antibodies: https://www.science.org/doi/full/10.1126/sciadv.adu8811 ___ Abonneer je op ons kanaal https://www.youtube.com/@googledeepmind Volg ons op X https://twitter.com/GoogleDeepMind Volg ons op Instagram https://instagram.com/googledeepmind Voeg ons toe op Linkedin https://www.linkedin.com/company/deepmind/

For half a century, scientists struggled to predict how proteins fold. A puzzle at the heart of understanding life and curing disease. Then, five years ago, the #alphafold team cracked the code. Since then, more than 3 million researchers across 190+ countries have used AlphaFold’s freely available database of 200 million+ protein structures, accelerating discoveries in everything from drug design to disease-resistant crops, bee conservation, and plastic-eating enzymes. Learn more: https://deepmind.google/blog/alphafold-five-years-of-impact Hear from Nobel Prize winner, John Jumper: https://youtu.be/-pGs0btGmgY ____ Further reading: Here are just a few examples of how researchers worldwide are using AlphaFold (in order of appearance): Chile, Germany: Engineering the catalytic activity of an Antarctic PET-degrading enzyme by loop exchange: https://onlinelibrary.wiley.com/doi/abs/10.1002/pro.4757 United Kingdom: AlphaFold-Multimer predicts cross-kingdom interactions at the plant-pathogen interface: https://www.nature.com/articles/s41467-023-41721-9 United States: Increasing thermostability of the key photorespiratory enzyme glycerate 3-kinase by structure-based recombination: https://onlinelibrary.wiley.com/doi/10.1111/pbi.14508 United States: The structure of apolipoprotein B100 from human low-density lipoprotein: https://www.nature.com/articles/s41586-024-08467-w Norway, Portugal, USA, UK: Cryo-EM structure of native honey bee vitellogenin: https://www.nature.com/articles/s41467-025-58575-y Spain: Identification of novel compounds against Trypanosoma cruzi using AlphaFold structures: https://linkinghub.elsevier.com/retrieve/pii/S2001037025001655 France: Structural basis for hepatitis E virus neutralization by potent human antibodies: https://www.science.org/doi/full/10.1126/sciadv.adu8811 ___ Subscribe to our channel https://www.youtube.com/@googledeepmind Find us on X https://twitter.com/GoogleDeepMind Follow us on Instagram https://instagram.com/googledeepmind Add us on Linkedin https://www.linkedin.com/company/deepmind/